Fentanyl, a synthetic opioid, is a major public health crisis in North America, leading to a surge in overdose deaths. Its potency, being 50 to 100 times stronger than morphine, and easy accessibility contribute to its misuse. The opioid epidemic stems from over-prescription and socioeconomic factors, worsened by the COVID-19 pandemic. The normalization of drug use and reduced stigma further complicate the issue, highlighting the need for comprehensive prevention and treatment strategies.